Prostate cancer risk variants of the HOXB genetic locus
نویسندگان
چکیده
منابع مشابه
Five genetic variants associated with prostate cancer.
n engl j med 358;25 www.nejm.org june 19, 2008 2738 less than originally planned. Landry and Oliver propose a three-group trial (norepinephrine alone, vasopressin alone, and the two combined), which raises two concerns. First, the sample-size requirements for three-group trials are onerous — much greater than those for two-group trials. Second, treating patients with vasopressin alone would be ...
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15 صفحه اولGenetic Association of the KLK4 Locus with Risk of Prostate Cancer
The Kallikrein-related peptidase, KLK4, has been shown to be significantly overexpressed in prostate tumours in numerous studies and is suggested to be a potential biomarker for prostate cancer. KLK4 may also play a role in prostate cancer progression through its involvement in epithelial-mesenchymal transition, a more aggressive phenotype, and metastases to bone. It is well known that genetic ...
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Mice with a disruption in the hoxb-2 locus were generated by gene targeting. 75% of the hoxb-2 mutant homozygotes died within 24 hours of birth. While a majority of these mice had severe sternal defects that compromised their ability to breathe, some had relatively normal sternum morphology, suggesting that one or more additional factor(s) contributed to neonatal lethality. At 3-3.5 weeks of ag...
متن کاملCommon genetic variants in prostate cancer risk prediction--results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3).
BACKGROUND One of the goals of personalized medicine is to generate individual risk profiles that could identify individuals in the population that exhibit high risk. The discovery of more than two-dozen independent single-nucleotide polymorphism markers in prostate cancer has raised the possibility for such risk stratification. In this study, we evaluated the discriminative and predictive abil...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-89399-7